Deep morphea induced by interferon-β1b injection
نویسندگان
چکیده
IFN: interferon ISR: injection site reaction MS: multiple sclerosis INTRODUCTION Morphea, also known as localized scleroderma, is an uncommon fibrosing condition of the skin and underlying tissue. Although the etiology is unknown, morphea is considered an autoimmune condition in which genetic and environmental factors contribute to disease onset. Although most cases are spontaneous, several inciting factors are associated with morphea, including trauma, surgery, radiotherapy, and infections. Morphea has also apparently been triggered by injections such as vaccination, vitamin B12, and vitamin K. However, morphea after interferon-b1b (IFN-b1b) injection is rarely reported. Injection site reactions (ISR) to IFNb1b range from mild erythema to ulceration, and a case of deep morphea after IFN-b1b injection is described here.
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